Causes
Destruction of the adrenal glands, almost always by an immune-mediated process. It mainly affects young to adult dogs. There is a breed predisposition.
Diagnosis
Blood tests (characteristic electrolyte disturbances) plus a specific hormonal test (ACTH stimulation test) that confirms the diagnosis.
Treatment
Lifelong treatment with the missing hormones. When well controlled, the dog leads a completely normal life. An Addisonian crisis is an emergency requiring hospitalisation.
Prevention
Not preventable. Early clinical suspicion prevents progression to an acute crisis.

